DELETION OF A PATHOGENIC MUTATION-CONTAINING EXON OF COL7A1 ALLOWS CLONAL GENE EDITING CORRECTION OF RDEB PATIENT EPIDERMAL STEM CELLS

Deletion of a Pathogenic Mutation-Containing Exon of COL7A1 Allows Clonal Gene Editing Correction of RDEB Patient Epidermal Stem Cells

Recessive dystrophic epidermolysis bullosa is a severe skin fragility disease caused by loss of functional type VII collagen at the dermal-epidermal junction.A frameshift mutation in exon 80 of COL7A1 gene, c.6527insC, is highly prevalent in Eye mask the Spanish patient population.We have implemented gene-editing strategies for COL7A1 frame restora

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Pressure drop mechanisms in a cooling system enclosure

A potential way to reduce the noise generated by construction machinery cooling systems is to satisfy the flow rate required for cooling at lower fan speeds, and a promising approach to achieving this goal involves finding ways to reduce the pressure drop that occurs in the cooling system ventilation passages.Towards that end, approaches using comp

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